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J Am Chem Soc. 2011 Sep 28;133(38):14912-5. doi: 10.1021/ja206095a. Epub 2011 Sep 2.

Emissive RNA alphabet.

Author information

1
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, United States.

Abstract

A fluorescent ribonucleoside alphabet consisting of highly emissive purine ((th)A, (th)G) and pyrimidine ((th)U, (th)C) analogues, all derived from thieno[3,4-d]pyrimidine as the heterocyclic nucleus, is described. Structural and biophysical analyses demonstrated that the emissive analogues are faithful isomorphic nucleoside surrogates. Photophysical analysis established that the nucleosides offer highly desirable qualities, including visible emission, high quantum yield, and responsiveness to environmental perturbations, traits entirely lacking in their native counterparts.

PMID:
21866967
PMCID:
PMC3179766
DOI:
10.1021/ja206095a
[Indexed for MEDLINE]
Free PMC Article

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