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Drug Discov Today. 2011 Sep;16(17-18):793-9. doi: 10.1016/j.drudis.2011.08.003. Epub 2011 Aug 16.

Novel advances in cytochrome P450 research.

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Department of Biotechnology and Bioinformatics, Ranbaxy Research Laboratories, R&D III, Sec 18, Udyog Vihar, Gurgaon 122015, Haryana, India.


The cytochrome P450 (CYP) enzymes, involved in the metabolism of therapeutic drugs, are the major determinants of drug half-life. From a drug industry perspective, variability in drug response owing to CYP polymorphisms makes CYP profiling a commercially interesting option for diagnosis, prognosis and predicting response to drug treatment. Recent studies highlighting microRNA-mediated regulation of CYP genes represents a major advance in our understanding of variations in individual drug responses. Herein we review new perspectives on the molecular mechanisms of CYP regulation and genotyping technologies. Together, these developments present novel therapeutic opportunities and help to explain the integrated response of cells to xenobiotic drug metabolism.

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