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Curr Opin Struct Biol. 2011 Oct;21(5):661-9. doi: 10.1016/j.sbi.2011.07.009. Epub 2011 Aug 22.

Visualizing kinetochore architecture.

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1
Biophysics Graduate Group, UC Berkeley, Berkeley, CA 94720, United States.

Abstract

Kinetochores are large macromolecular assemblies that link chromosomes to spindle microtubules (MTs) during mitosis. Here we review recent advances in the study of core MT-binding kinetochore complexes using electron microcopy methods in vitro and nanometer-accuracy fluorescence microscopy in vivo. We synthesize these findings in novel three-dimensional models of both the budding yeast and vertebrate kinetochore in different stages of mitosis. There is a growing consensus that kinetochores are highly dynamic, supra-molecular machines that undergo dramatic structural rearrangements in response to MT capture and spindle forces during mitosis.

PMID:
21862320
PMCID:
PMC3189262
DOI:
10.1016/j.sbi.2011.07.009
[Indexed for MEDLINE]
Free PMC Article
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