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Curr Opin Immunol. 2011 Dec;23(6):808-13. doi: 10.1016/j.coi.2011.07.015. Epub 2011 Aug 19.

Allergic rhinitis and asthma: celebrating 100 years of immunotherapy.

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Creighton University School Medicine, Department of Medicine, Allergy/Immunology Division, Omaha, NE 68131, United States.


Since Noon first described allergen immunotherapy a century ago the basic premise of subcutaneous injections (SCIT) of relevant aeroallergens to induce clinical tolerance has remained true [1]. Indeed, allergen immunotherapy did not change dramatically over the first 75 years, but over the past 25 years there have been a number of important advancements leading to newer approaches and novel formulations. Here we review the top 50 articles published in the past 2 years on allergens, environmental control, and immunotherapy for asthma and allergic rhinitis and the use of immunomodulators in allergic disease.

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