Send to

Choose Destination
Hautarzt. 2011 Sep;62(9):677-82. doi: 10.1007/s00105-011-2160-7.

[In vitro diagnosis and monitoring of Hymenoptera venom hyposensitization].

[Article in German]

Author information

Hautklinik - Klinik f├╝r Dermatologie und Allergologie, Universit├Ątsklinikum der RWTH Aachen, Aachen, Deutschland.


Specific immunotherapy (SIT) of hymenoptera venom allergy, in particular, has become an example for the effectiveness of the treatment of IgE-mediated allergic diseases. In vitro diagnostic procedures and the measurement of serum tryptase for risk assessment are well-established in the process of diagnose finding and therapy preparation. For monitoring and validation of the effectiveness of the SIT, however, in vitro diagnostic procedures remain controversial. Potentially useful approaches include detection of specific IgE, specific IgG4, basophile activation - represented by the CD 63 expression - and the lymphocyte proliferation and its IL10 release. Preliminary data suggest that the latter method appear appropriate, whereas the detection of basophile activation did not produce definite results.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center