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Nat Rev Mol Cell Biol. 2011 Aug 23;12(9):605-20. doi: 10.1038/nrm3173.

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.

Author information

1
Laboratory of Protein Dynamics and Signalling, National Cancer Institute, Frederick, Maryland 21702, USA. amw@nih.gov

Erratum in

  • Nat Rev Mol Cell Biol. 2011 Oct;12(10):686.

Abstract

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular processes in eukaryotes through highly specific modification of numerous cellular proteins, which is often tightly regulated in a spatial and temporal manner. Although most often associated with proteasomal degradation, ubiquitylation frequently serves non-proteolytic functions. In light of its central roles in cellular regulation, it has not been surprising to find that many of the components of the ubiquitin system itself are regulated by ubiquitylation. This observation has broad implications for pathophysiology.

PMID:
21860393
PMCID:
PMC3545438
DOI:
10.1038/nrm3173
[Indexed for MEDLINE]
Free PMC Article

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