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Pediatr Infect Dis J. 2012 Jan;31(1):89-90. doi: 10.1097/INF.0b013e31822fb15d.

Hospital course and short-term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis.

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Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.


Our objective was to characterize the hospital course and short-term outcomes of neonates exposed to prolonged rupture of membranes (PROM), chorioamnionitis (CH), or both PROM and CH. Outcomes were positive blood culture and/or clinical signs of infection (+BC/CSI) prompting >4 days of antibiotics. Six neonates had a positive BC, 2 (0.6%) in the CH group and 4 (2.7%) in the PROM + CH group (P = 0.05); none of the neonates exposed to PROM alone had a +BC. These results support our current approach of withholding routine antibiotic therapy in neonates exposed to PROM alone.

[Indexed for MEDLINE]

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