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J Innate Immun. 2012;4(2):213-8. doi: 10.1159/000329550. Epub 2011 Aug 19.

Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.

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1
Division of Pharmacology and Drug Discovery, Department of Pediatrics, University of California, San Diego, Calif., USA. annelies.zinkernagel @ usz.ch

Abstract

Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.

PMID:
21860217
PMCID:
PMC3388268
DOI:
10.1159/000329550
[Indexed for MEDLINE]
Free PMC Article
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