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Antimicrob Agents Chemother. 2011 Nov;55(11):5403-7. doi: 10.1128/AAC.00585-11. Epub 2011 Aug 22.

Genetic features of blaNDM-1-positive Enterobacteriaceae.

Author information

1
Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le-Kremlin-Bicêtre cedex, France.

Abstract

Genetic features associated with the bla(NDM-1) gene were investigated in 6 Escherichia coli, 7 Klebsiella pneumoniae, 1 Citrobacter freundii, 1 Proteus mirabilis, and 1 Providencia stuartii isolate of worldwide origin. Clonal diversity was observed for both E. coli and K. pneumoniae. The bla(NDM-1) gene was carried by different plasmid types (IncA/C, IncF, IncL/M, or untypeable) and was likely chromosome borne in two isolates. The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes.

PMID:
21859933
PMCID:
PMC3195013
DOI:
10.1128/AAC.00585-11
[Indexed for MEDLINE]
Free PMC Article

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