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J Card Surg. 2011 Sep;26(5):492-4. doi: 10.1111/j.1540-8191.2011.01293.x. Epub 2011 Aug 22.

Detrimental effects of divalproex on warfarin therapy following mechanical valve replacement.

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Department of Psychiatry, The Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA.


Drug interaction between Warfarin and psychiatric agents may have important therapeutic effects for patients undergoing cardiac surgery. We present a case of a patient in whom concurrent treatment with Warfarin and valproic acid resulted in supratherapeutic international normalized ratio values. A discussion of the possible mechanisms for this interaction as well as a review of interactions between Warfarin and other psychiatric medications is the subject of this case report.

[Indexed for MEDLINE]

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