Format

Send to

Choose Destination
J Am Chem Soc. 2011 Sep 21;133(37):14488-91. doi: 10.1021/ja204546h. Epub 2011 Aug 29.

Photo-cross-linking-assisted thermal stability of DNA origami structures and its application for higher-temperature self-assembly.

Author information

1
Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.

Abstract

Heat tolerance of DNA origami structures has been improved about 30 °C by photo-cross-linking of 8-methoxypsoralen. To demonstrate one of its applications, the cross-linked origami were used for higher-temperature self-assembly, which markedly increased the yield of the assembled product when compared to the self-assembly of non-cross-linked origami at lower-temperature. By contrast, at higher-temperature annealing, native non-cross-linked tiles did not self-assemble to yield the desired product; however, they formed a nonspecific broken structure.

PMID:
21859143
DOI:
10.1021/ja204546h
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center