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Biotechnol Lett. 2011 Dec;33(12):2481-6. doi: 10.1007/s10529-011-0728-z. Epub 2011 Aug 21.

Streptomyces ghanaensis pleiotropic regulatory gene wblA(gh) influences morphogenesis and moenomycin production.

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Department of Genetic and Biotechnology, Ivan Franko National University of Lviv, Grushevskogo St. 4, Lviv 79005, Ukraine.


The wblA(gh) gene, encoding a homologue of the WhiB-family of proteins, was identified in the sequenced genome of moenomycin producer Streptomyces ghanaensis. Deletion of the gene blocked aerial mycelium sporulation and caused a 230% increase in moenomycins production. S. ghanaensis overexpressing SSFG-01620: a homologue of extracellular protease inhibitor SCO0762, whose expression in Streptomyces coelicolor is down-regulated by wblA: showed deficiencies in sporulation similar to that of wblA(gh) knockout strain. The wblA(gh) gene of S. ghanaensis appears to play a negative role in the control of moenomycin biosynthesis and is essential for sporulation.

[Indexed for MEDLINE]

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