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Z Rheumatol. 2011 Sep;70(7):567-72. doi: 10.1007/s00393-011-0812-8.

[Gastrointestinal tumors. Clinical manifestations of paraneoplastic rheumatic symptoms].

[Article in German]

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Zentrum für Innere Medizin, Nordwest Krankenhaus Sanderbusch, Hauptstrasse, Sande, Germany.


Paraneoplastic syndromes, as syndromes associated with malignancy, can present unrelated to tumor invasion or metastases. They can occur with varying clinical appearance and are often indistinguishable from idiopathic rheumatic symptoms. Some musculoskeletal disorders are more associated with malignancies. The therapy of rheumatic syndromes can itself have an effect on the tumorigenic process. The clinical severity of paraneoplastic rheumatic symptoms can in many cases aid in the assessment of tumor activity and the response to therapy. While generally an extensive search for occult malignancies in every older rheumatoid patient in cases with no indications of malignancy is not advisable, knowledge of rheumatic symptoms associated with malignancies aids in the important early detection of tumors, while avoiding unnecessary examinations.

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