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Nat Immunol. 2011 Aug 21;12(10):992-1001. doi: 10.1038/ni.2086.

The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.

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1
Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA.

Erratum in

  • Nat Immunol. 2013 Apr;14(4):413.

Abstract

It is established that the transcription factor E2A and its antagonist Id3 modulate the checkpoints consisting of the precursor to the T cell antigen receptor (pre-TCR) and the TCR. Here we demonstrate that Id3 expression was higher beyond the pre-TCR checkpoint, remained high in naive T cells and showed a bimodal pattern in the effector-memory population. We show how E2A promoted T lineage specification and how pre-TCR-mediated signaling affected E2A genome-wide occupancy. Thymi in Id3-deficient mice had aberrant development of effector-memory cells, higher expression of the chemokine receptor CXCR5 and the transcriptional repressor Bcl-6 and, unexpectedly, T cell-B cell conjugates and B cell follicles. Collectively, our data show how E2A acted globally to orchestrate development into the T lineage and that Id3 antagonized E2A activity beyond the pre-TCR checkpoint to enforce the naive fate of T cells.

PMID:
21857655
PMCID:
PMC3178719
DOI:
10.1038/ni.2086
[Indexed for MEDLINE]
Free PMC Article
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