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Neurosciences (Riyadh). 2007 Jan;12(1):25-30.

Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke.

Author information

  • 1Department of 1st Neurology, Haydarpasa Numune Educational and Research Hospital, 50 Ada Akasya 1/2 Blok D:11 Atasehir 81120 Kadikoy-Istanbul, Turkey. Tel. +90 (216) 4556758. Fax. +90 (262) 7511267. E-mail: fusundomac@yahoo.com.tr.

Abstract

OBJECTIVE:

To assess the implication of tumor necrosis factor alpha (TNF-alpha) and interleukine-6 (IL-6) in acute ischemic stroke and to correlate this with lesion size, vascular risk factors, and neurological impairment.

METHODS:

We included 70 patients consecutively admitted to the Department of 1st Neurology, Haydarpasa Numune Educational and Research Hospital, Istanbul, Turkey, between September 2001 and April 2002, with first-ever ischemic cerebral infarction within the first 24 hours from onset. The TNF-alpha, IL-6, fibrinogen, C-reactive protein, erythrocyte sedimentation rate (ESR) and leukocytes were determined in plasma on admission. Neurological impairment was evaluated with the modified Rankin Scale.

RESULTS:

We found higher baseline levels of TNF-alpha and IL-6 in the plasma of patients with acute ischemic stroke and neurological impairment in comparison to control subjects. In the large infarct group, TNF-alpha, IL-6, low-density lipoprotein-cholesterol and fibrinogen were found significantly higher compared to the small infarct group. While an association between TNF-alpha and IL-6 values and lesion size were determined, no relation was found between localization and etiology. The TNF-alpha level was found to be in positive correlation with IL-6, fibrinogen, and ESR. The IL-6 level was found to be in positive correlation with ESR fibrinogen, and leukocytes.

CONCLUSION:

Inflammatory findings are associated with the early stage of ischemic stroke. The TNF-alpha and IL-6 were also higher in patients with clinical worsening. The release of proinflammatory cytokines after focal cerebral ischemia indicates a step leading to tissue necrosis or reflects the amount of ischemic brain injury, since the higher concentrations of TNF-alpha and IL-6 are found in patients with large infarctions.

PMID:
21857614
[PubMed]
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