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Pharmacol Rep. 2011;63(3):840-4.

Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus.

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Department of General Physiology of Nervous System, Bogomoletz Institute of Physiology, Bogomoletz st. 4, Kiev, Ukraine.


Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg²⁺ seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined the effectiveness of desialylation in reducing persistent seizure-like activity. We show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low Mg²⁺. These findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus.

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