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Mol Oncol. 2011 Aug;5(4):315-23. doi: 10.1016/j.molonc.2011.07.007. Epub 2011 Jul 30.

p53: guardian of ploidy.

Author information

1
Department of Molecular Cell Biology, The Weizmann Institute of Science, PO Box 26, Rechovot 76100, Israel. yael.aylon@weizmann.ac.il

Abstract

Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed, both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive neoplastic transformation and cancer progression. True to form, the tumor suppressor p53 obstructs propagation of these dangerous chromosomal events by either instigating irreversible cell cycle arrest or apoptosis. The tumor suppressor Lats2, along with other tumor inhibitory proteins such as BRCA1/2 and BubR1, are central to p53-dependent elimination of tetraploid cells. Not surprisingly, these proteins are frequently inactivated or downregulated in tumors, synergizing with p53 inactivation to establish an atmosphere of "tolerance" for a non-diploid state.

PMID:
21852209
PMCID:
PMC3164924
DOI:
10.1016/j.molonc.2011.07.007
[Indexed for MEDLINE]
Free PMC Article

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