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Comput Biol Med. 2011 Dec;41(12):1100-9. doi: 10.1016/j.compbiomed.2011.07.008. Epub 2011 Aug 17.

Anatomic and electro-physiologic connectivity of the language system: a combined DTI-CCEP study.

Author information

1
Vivian L. Smith Department of Neurosurgery, University of Texas Medical School at Houston, USA.

Abstract

Here we present a novel multimodal analysis of network connectivity in the language system. We assessed connectivity of Broca's area using tractography with diffusion tensor imaging (DTI), and with cortico-cortical evoked potentials (CCEPs) to measure the spread of artificial currents applied directly to human cortex. We found that both the amplitude and latency of CCEP currents significantly correlates (r(2)=0.41, p<10(-16)) with the number of DTI pathways connecting the stimulation and recording loci. This strategy of relating electrical information flow with the neural architecture will likely yield new insights into cognitive processes.

PMID:
21851933
PMCID:
PMC3223284
DOI:
10.1016/j.compbiomed.2011.07.008
[Indexed for MEDLINE]
Free PMC Article

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