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Liver Transpl. 2011 Nov;17 Suppl 3:S20-3. doi: 10.1002/lt.22414.

Hot-topic debate on hepatitis C virus: the type of immunosuppression matters.

Author information

1
Baylor University Medical Center, Dallas, TX 75246, USA. james.trotter@baylorhealth.edu

Abstract

1. The treatment of rejection is an important factor associated with the severe recurrence of hepatitis C virus (HCV) after liver transplantation. 2. The effects of calcineurin inhibitors, corticosteroids, and mycophenolate mofetil on HCV recurrence are equivocal. 3. Cyclosporine is associated with a higher sustained virological response in patients treated for HCV. 4. Because insulin resistance and diabetes are associated with fibrosis in HCV-infected liver transplant recipients, the use of immunosuppressive agents without this side effect may slow the posttransplant disease progression.

PMID:
21850693
DOI:
10.1002/lt.22414
[Indexed for MEDLINE]
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