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Osteoporos Int. 2011 Oct;22(10):2597-602. doi: 10.1007/s00198-011-1740-9. Epub 2011 Aug 18.

Relationship between serum RANKL and RANKL in bone.

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Discipline of Orthopaedics and Trauma, University of Adelaide, Level 4 Bice Building, Royal Adelaide Hospital, Adelaide 5000, SA, Australia.


It is now well accepted that the molecule receptor activator of NF╬║B ligand (RANKL) and osteoprotegerin play key roles in regulating physiological and pathological bone turnover. There are a large number of published reports of circulating RANKL levels in both health and pathology. However, interpretation of these data has been elusive, and the relationship between circulating RANKL and RANKL levels in bone is still not clear. This review explores this subject, documenting the possible origins of circulating RANKL and suggesting additional information that is required before serum RANKL levels can provide useful diagnostic or research information.

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