Format

Send to

Choose Destination
See comment in PubMed Commons below
J Pharmacol Exp Ther. 2011 Nov;339(2):324-8. doi: 10.1124/jpet.111.183285. Epub 2011 Aug 17.

Drug discontinuation effects are part of the pharmacology of a drug.

Author information

1
Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA. mmreid@med.cornell.edu

Abstract

Most reviews of drug withdrawal effects focus on drugs of potential abuse such as opioids, benzodiazepines, etc. Abrupt discontinuation of many other drugs used in medicine cause withdrawal syndromes, some of which can be fatal. Discontinuation of a number of cardiovascular drugs can increase risk of cardiovascular events above that of people not taking these drugs. These include β-adrenergic receptor antagonists, aspirin, HMG-CoA reductase inhibitors (statins), and heparin. Rebound hypertension occurs after abrupt cessation of many antihypertensive drugs. The possibility of discontinuation syndromes has usually been neglected until adverse clinical events force them to be noticed. Attention to the possibility of drug discontinuation effects is an important part of drug safety evaluation.

PMID:
21849624
PMCID:
PMC3200000
DOI:
10.1124/jpet.111.183285
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center