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J Infect Dis. 2011 Sep 15;204(6):937-41. doi: 10.1093/infdis/jir441.

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection.

Author information

1
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, and Bethesda, Maryland, USA.

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are frequently associated with strains harboring genes encoding Panton-Valentine leukocidin (PVL). The role of PVL in the success of the epidemic CA-MRSA strain USA300 remains unknown. Here we developed a skin and soft tissue infection model in rabbits to test the hypothesis that PVL contributes to USA300 pathogenesis and compare it with well-established virulence determinants: alpha-hemolysin (Hla), phenol-soluble modulin-alpha peptides (PSMα), and accessory gene regulator (Agr). The data indicate that Hla, PSMα, and Agr contribute to the pathogenesis of USA300 skin infections in rabbits, whereas a role for PVL could not be detected.

PMID:
21849291
PMCID:
PMC3156927
DOI:
10.1093/infdis/jir441
[Indexed for MEDLINE]
Free PMC Article

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