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J Infect Dis. 2011 Sep 15;204(6):912-8. doi: 10.1093/infdis/jir416.

Natural cholera infection-derived immunity in an endemic setting.

Author information

1
International Vaccine Institute, Seoul, Republic of Korea. mali@ivi.int

Abstract

BACKGROUND:

Live oral cholera vaccines may protect against cholera in a manner similar to natural cholera infections. However, information on which to base these vaccines is limited.

METHODS:

The study was conducted in a cholera-endemic population in Bangladesh. Patients with cholera (index patients) detected between 1991 and 2000 were age-matched to 4 cholera-free controls and then followed up during the subsequent 3 years.

RESULTS:

El Tor cholera was associated with a 65% (95% confidence interval [CI], 37%-81%; P < .001) lower risk of a subsequent El Tor episode. Reduction of the risk of subsequent El Tor cholera was similar for children < 5 years and for older persons and was sustained during all 3 years of follow-up. Having El Tor Inaba cholera was associated with lower risks of both El Tor Inaba and El Tor Ogawa cholera, but having El Tor Ogawa cholera was associated only with a reduced risk of El Tor Ogawa cholera. O139 cholera was associated with a 63% (95% CI, -61% to 92%; P = .18) lower risk of subsequent O139 cholera, but there was no evidence of cross-protection between the O1 and O139 serogroups.

CONCLUSIONS:

Live oral cholera vaccines designed to protect against the O1 and O139 serogroups should contain at least the Inaba serotype and strains of both serogroups.

PMID:
21849288
PMCID:
PMC3156915
DOI:
10.1093/infdis/jir416
[Indexed for MEDLINE]
Free PMC Article
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