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Br J Haematol. 2011 Oct;155(2):137-49. doi: 10.1111/j.1365-2141.2011.08826.x. Epub 2011 Aug 16.

Anticoagulating obese patients in the modern era.

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King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital Foundation NHS Trust, London, UK.


The prevalence of obesity has increased substantially over recent years. Clinicians are increasingly being challenged with making uncertain anticoagulant dosing decisions, as the optimal dosing strategy for most anticoagulants in the obese patient population remains unknown. Research published to date suggests that the clearance of anticoagulants increases with weight. As obesity is associated with an increased risk of venous thromboembolism and arterial disease, there is an urgent need to establish appropriate anticoagulation regimens for this patient group. Research studies applying the method of pharmacokinetic-pharmacodynamic modelling and simulation could establish an appropriate evidence base and provide direction and reassurance to prescribing clinicians.

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