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AIDS Res Hum Retroviruses. 2012 Jan;28(1):54-75. doi: 10.1089/AID.2011.0230. Epub 2011 Sep 21.

HIV type 1 Gag as a target for antiviral therapy.

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1
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland 21702-1201, USA. waheedab@mail.nih.gov

Abstract

The Gag proteins of HIV-1 are central players in virus particle assembly, release, and maturation, and also function in the establishment of a productive infection. Despite their importance throughout the replication cycle, there are currently no approved antiretroviral therapies that target the Gag precursor protein or any of the mature Gag proteins. Recent progress in understanding the structural and cell biology of HIV-1 Gag function has revealed a number of potential Gag-related targets for possible therapeutic intervention. In this review, we summarize our current understanding of HIV-1 Gag and suggest some approaches for the development of novel antiretroviral agents that target Gag.

PMID:
21848364
PMCID:
PMC3251841
DOI:
10.1089/AID.2011.0230
[Indexed for MEDLINE]
Free PMC Article
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