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J Am Chem Soc. 2011 Sep 21;133(37):14507-9. doi: 10.1021/ja204275t. Epub 2011 Aug 24.

Imaging multiple conductance states in an alamethicin pore.

Author information

1
Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

Abstract

Alamethicin is the archetypal antimicrobial pore-forming peptide. Although the peptide has long been known to form pores of characteristic conductances in lipid membranes, the precise nature of these pores is not known. Simultaneous calcium-flux imaging and single-channel recording in a droplet interface bilayer allowed us to directly attribute multiple conductance states to a single point diffusing in the bilayer.

PMID:
21848341
DOI:
10.1021/ja204275t
[Indexed for MEDLINE]

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