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Dig Dis Sci. 2012 Jan;57(1):161-9. doi: 10.1007/s10620-011-1852-2. Epub 2011 Aug 17.

Decreased colorectal cancer and adenoma risk in patients with microscopic colitis.

Author information

1
Division of Gastroenterology, Pritzker School of Medicine, University of Chicago, NorthShore University HealthSystem, 2650 Ridge Avenue, Suite G221, Evanston, IL 60201, USA. eyen@uchicago.edu

Abstract

INTRODUCTION:

Microscopic colitis is currently considered to harbor no increased risk for colorectal cancer, based on a few small studies with limited long-term follow-up. Our aim was to identify patients with microscopic colitis, and to compare long-term rates of colorectal cancer or adenoma to a control group of patients without microscopic colitis.

METHODS:

We reviewed the records of patients diagnosed with microscopic colitis, as identified by a hospital-based pathology database from January 2000 to August 2008. Clinical factors, including history of adenoma or adenocarcinoma, and all colonoscopy findings, were recorded. Age and gender-matched patients without microscopic colitis served as the control in a 1:1 fashion.

RESULTS:

A total of 647 patients (153 male: 494 female) were identified with microscopic colitis (MC). Any history of colorectal cancer was detected in 1.92, 1.81, and 4.17% of patients with collagenous colitis (CC), lymphocytic colitis (LC), and controls, respectively (P = 0.095, P = 0.040, P = 0.015 for CC, LC, and all MC, respectively, comparing to controls). Overall, covariate-adjusted risk (odds ratio) of any history of colorectal cancer and colorectal adenoma in MC patients was 0.34 (95% confidence interval [CI] 0.16-0.73, P = 0.006) and 0.52 (95% CI 0.50-0.76, P < 0.0001), respectively. The mean duration of follow-up was 4.63 years, with 147/647 (22.7%) of patients with clinical follow-up >7 years.

CONCLUSIONS:

In this case-control study involving a large retrospective cohort, microscopic colitis is negatively associated with the risk for colorectal cancer and adenoma. Further studies are required to determine a temporal relationship between microscopic colitis and the future development of colorectal neoplasia.

PMID:
21847567
DOI:
10.1007/s10620-011-1852-2
[Indexed for MEDLINE]

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