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Int J Womens Health. 2011;3:213-7. doi: 10.2147/IJWH.S20557. Epub 2011 Jul 20.

Fetal gender ratio in recurrent miscarriages.

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1
Clinic of Obstetrics and Gynecology.

Abstract

BACKGROUND:

The purpose of this study was to evaluate the gender ratio and incidence of chromosomal anomalies in the products of conception (POC) from recurrent miscarriages.

METHODS:

We determined the karyotypes of POC from patients with recurrent spontaneous miscarriages between 1999 and 2009.

RESULTS:

In total, 313 specimens were successfully karyotyped, with a median gestational age of 10 weeks at miscarriage (interquartile range 8-13); 199 (64%) were females and 114 (36%) were males. In total, 121 (39%) had abnormal karyotypes, the most prevalent of which were chromosome 21 and 16 trisomies, triploidy, and monosomy X.

CONCLUSION:

Our findings suggest that female POC might be more susceptible to recurrent miscarriages than male ones during embryogenesis, implantation, and initial fetal development.

KEYWORDS:

fetal gender; karyotype anomalies; recurrent miscarriages

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