Format

Send to

Choose Destination
J Biomed Biotechnol. 2011;2011:835968. doi: 10.1155/2011/835968. Epub 2011 Aug 7.

Histone deacetylases in neural stem cells and induced pluripotent stem cells.

Author information

1
Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

Abstract

Stem cells have provided great hope for the treatment of a variety of human diseases. However, the molecular mechanisms underlying stem cell pluripotency, self-renewal, and differentiation remain to be unveiled. Epigenetic regulators, including histone deacetylases (HDACs), have been shown to coordinate with cell-intrinsic transcription factors and various signaling pathways to regulate stem cell pluripotency, self-renewal, and fate determination. This paper focuses on the role of HDACs in the proliferation and neuronal differentiation of neural stem cells and the application of HDAC inhibitors in reprogramming somatic cells to induced pluripotent stem cells (iPSCs). It promises to be an active area of future research.

PMID:
21845024
PMCID:
PMC3154389
DOI:
10.1155/2011/835968
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Publishing Corporation Icon for PubMed Central
Loading ...
Support Center