Format

Send to

Choose Destination
See comment in PubMed Commons below
Immunol Cell Biol. 2012 Jul;90(6):571-8. doi: 10.1038/icb.2011.70. Epub 2011 Aug 16.

Return of inactivated whole-virus vaccine for superior efficacy.

Author information

1
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208-3479, USA. furuyay@mail.amc.edu

Abstract

The swine, influenza, H1N1 outbreak in 2009 highlighted the inadequacy of the currently used antibody-based vaccine strategies as a preventive measure for combating influenza pandemics. The ultimate goal for successful control of newly arising influenza outbreaks is to design a single-shot vaccine that will provide long-lasting immunity against all strains of influenza A virus. A large amount of data from animal studies has indicated that the cross-reactive cytotoxic T (Tc) cell response against conserved influenza virus epitopes may be the key immune response needed for a universal influenza vaccine. However, decades of research have shown that the development of safe T-cell-based vaccines for influenza is not an easy task. Here, I discuss the overlooked but potentially highly advantageous inactivation method, namely, γ-ray irradiation, as a mean to reach the Holy Grail of influenza vaccinology.

PMID:
21844883
DOI:
10.1038/icb.2011.70
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center