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J Atheroscler Thromb. 2011;18(10):867-73. Epub 2011 Aug 16.

Depleted leukocyte mitochondrial DNA copy number in metabolic syndrome.

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1
Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.

Abstract

AIMS:

Metabolic syndrome (MetS) is characterized by a group of defects of metabolic origin which are possibly involved in mitochondrial DNA (mtDNA) alteration of mtDNA content [Lee et al. Exp Biol Med, 2007; 232(5):592-606]. The present study was undertaken to ascertain whether alteration of leukocyte mtDNA copy number is related to MetS.

METHODS:

Eighty non-MetS subjects and 50 subjects with MetS were recruited. The mtDNA copy number of leukocytes from each group of subjects was measured using quantitative polymerase chain reaction.

RESULTS:

The mtDNA copy number of leukocytes in subjects with MetS was significantly lower than that of non-MetS subjects. Depleted mtDNA copy number is correlated with lower plasma HDL, higher triglyceride, higher HOMA-IR and hypertension, and is even more sensitive to MetS criteria.

CONCLUSIONS:

Depleted leukocyte mtDNA copy number is related to the severity of MetS. Alteration of mtDNA copy number in leukocytes is proposed as a MetS biomarker involved in the bioenergetic change of mitochondria.

PMID:
21844659
[Indexed for MEDLINE]
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