Format

Send to

Choose Destination
Neurosci Lett. 2011 Sep 26;503(1):10-4. doi: 10.1016/j.neulet.2011.07.053. Epub 2011 Aug 6.

SOD1 overexpression improves features of the oligodendrocyte precursor response in vitro.

Author information

1
Brain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, United States.

Abstract

Spinal cord injury (SCI) produces a significant loss of oligodendrocytes (OL) and demyelination. The oligodendrocyte precursor cells (OPCs) response includes a group of cellular changes in OPCs that are directed to replenish OL loss from the injury. However, this adaptive response is hampered and OPCs eventually die or fail to differentiate to mature and functional OL. In this study, we wanted to evaluate if overexpression of human superoxide dismutase 1 (hSOD1) in OPCs from the SOD1 transgenic rat could improve some of the features of the OPC response in vitro. We found that hSOD1 overexpression increases the proliferation of OPCs and accelerates their differentiation to mature OL in vitro. Furthermore, hSOD1 overexpression reduces oxidative stress-mediated death in OPCs. These results suggest hSOD1 as a therapeutic target to increase OPC response success and potentially, OL replacement and remyelination after SCI.

PMID:
21843597
PMCID:
PMC3171518
DOI:
10.1016/j.neulet.2011.07.053
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center