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Nat Neurosci. 2011 Aug 14;14(9):1115-7. doi: 10.1038/nn.2891.

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory.

Author information

1
Intellectual Development and Disabilities Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.

Abstract

MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.

PMID:
21841775
DOI:
10.1038/nn.2891
[Indexed for MEDLINE]

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