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Physiology (Bethesda). 2011 Aug;26(4):236-51. doi: 10.1152/physiol.00051.2010.

New insights into HIV assembly and trafficking.

Author information

1
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA.

Abstract

Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag trafficking is currently one of the least understood aspects of HIV-1 replication. In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly.

PMID:
21841072
PMCID:
PMC3467973
DOI:
10.1152/physiol.00051.2010
[Indexed for MEDLINE]
Free PMC Article

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