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Chronic Illn. 2011 Dec;7(4):279-90. doi: 10.1177/1742395311407532. Epub 2011 Aug 12.

Long-term effects of a community-based lifestyle intervention to prevent type 2 diabetes: the DEPLOY extension pilot study.

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Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.



The US Diabetes Prevention Program (DPP) and other large trials internationally have shown that an intensive lifestyle intervention can reduce the development of type 2 diabetes. We evaluated long-term effects of a lower cost, group-based adaption of the DPP lifestyle intervention offered by the YMCA.


Participants were adults with BMI ≥24 kg/m(2) and random capillary blood glucose 6.1-11.1 mmol/L who had been previously enrolled in a cluster-randomized trial comparing a group-based DPP lifestyle intervention versus brief advice alone. Four to 12 months after completion of the initial trial, 72% of 92 participants enrolled in an extension study, and all were offered a group lifestyle maintenance program at the YMCA. Paired t-tests were used to assess within-group changes; ANCOVA with adjustment was used for between-group comparisons.


At 28 months, after both arms were offered the same 8-month lifestyle maintenance intervention, both arms had statistically significant weight losses compared to baseline (brief advice controls: -3.6%; 95% CI: -5.8 to -1.4; intensive lifestyle: -6.0%; 95% CI: -8.8 to -3.2). Participants initially assigned to the DPP also experienced significant improvements in blood pressure and total cholesterol.


The YMCA is a promising channel for dissemination of a low-cost model for lifestyle diabetes prevention. Future studies are needed to verify these findings.

[Indexed for MEDLINE]

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