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Consult Pharm. 2011 Aug;26(8):530-42. doi: 10.4140/TCP.n.2011.530.

When medications make pain worse: opioid-induced hyperalgesia.

Author information

1
consultant pharmacist, Greensboro, North Carolina.

Abstract

Opioid medications are commonly used to treat moderate-to-severe pain. While these medications are generally an effective means of pain control, they can, in rare cases, actually exacerbate the pain. This paradoxical reaction is called opioid-induced hyperalgesia (OIH). Patients experiencing OIH may benefit from decreasing or discontinuing the opioid, switching to an alternative opioid, and/or using a nonopioid medication for pain.

PMID:
21840817
DOI:
10.4140/TCP.n.2011.530
[Indexed for MEDLINE]

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