Send to

Choose Destination
Curr Opin Microbiol. 2011 Oct;14(5):550-5. doi: 10.1016/j.mib.2011.07.026. Epub 2011 Aug 11.

Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors.

Author information

Arietis Corp, Boston, MA 02118, United States.


The β-lactams have been among the most successful classes of antibacterial agents for the past half century. However, a disturbing increase in resistance to β-lactams has been noted among Gram-negative bacteria, which is attributable to β-lactamase enzymes not within the spectrum of currently marketed β-lactams or β-lactam/β-lactamase inhibitor combinations. Diazabicyclooctanes (DBOs) were first investigated as β-lactam mimics in the mid-1990s by chemists at Hoechst Marion Roussel (now part of Sanofi-Aventis) and proved to be a rich source of β-lactamase inhibitors (BLI). Two members of this novel series of highly potent, broad spectrum BLIs are now in clinical development and their properties are reviewed here.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center