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Curr Opin Microbiol. 2011 Oct;14(5):550-5. doi: 10.1016/j.mib.2011.07.026. Epub 2011 Aug 11.

Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors.

Author information

1
Arietis Corp, Boston, MA 02118, United States. k.coleman@arietiscorp.com

Abstract

The β-lactams have been among the most successful classes of antibacterial agents for the past half century. However, a disturbing increase in resistance to β-lactams has been noted among Gram-negative bacteria, which is attributable to β-lactamase enzymes not within the spectrum of currently marketed β-lactams or β-lactam/β-lactamase inhibitor combinations. Diazabicyclooctanes (DBOs) were first investigated as β-lactam mimics in the mid-1990s by chemists at Hoechst Marion Roussel (now part of Sanofi-Aventis) and proved to be a rich source of β-lactamase inhibitors (BLI). Two members of this novel series of highly potent, broad spectrum BLIs are now in clinical development and their properties are reviewed here.

PMID:
21840248
DOI:
10.1016/j.mib.2011.07.026
[Indexed for MEDLINE]

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