Format

Send to

Choose Destination
Dev Cell. 2011 Aug 16;21(2):366-74. doi: 10.1016/j.devcel.2011.06.021.

Steep differences in wingless signaling trigger Myc-independent competitive cell interactions.

Author information

1
MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. jvincen@nimr.mrc.ac.uk

Abstract

Wnt signaling is a key regulator of development that is often associated with cancer. Wingless, a Drosophila Wnt homolog, has been reported to be a survival factor in wing imaginal discs. However, we found that prospective wing cells survive in the absence of Wingless as long as they are not surrounded by Wingless-responding cells. Moreover, local autonomous overactivation of Wg signaling (as a result of a mutation in APC or axin) leads to the elimination of surrounding normal cells. Therefore, relative differences in Wingless signaling lead to competitive cell interactions. This process does not involve Myc, a well-established cell competition factor. It does, however, require Notum, a conserved secreted feedback inhibitor of Wnt signaling. We suggest that Notum could amplify local differences in Wingless signaling, thus serving as an early trigger of Wg signaling-dependent competition.

PMID:
21839923
PMCID:
PMC3209557
DOI:
10.1016/j.devcel.2011.06.021
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center