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Semin Cell Dev Biol. 2011 Sep;22(7):759-68. doi: 10.1016/j.semcdb.2011.07.022. Epub 2011 Aug 4.

Interactions between subunits of the Mediator complex with gene-specific transcription factors.

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Max-Planck-Institute of Immunobiology and Epigenetics, Stübeweg 51, D-79108 Freiburg, Germany.


The Mediator complex forms the bridge between gene-specific transcription factors and the RNA polymerase II (RNAP II) machinery. Mediator is a large polypetide complex consisting of about thirty polypeptides that are mostly conserved from yeast to human. Mediator coordinates RNAP II recruitment, phosphorylation of the C-terminal domain of RNAP II, enhancer-loop formation and post-initiation events. The focus of the review is to summarize the current knowledge of transcription factor/Mediator interactions in higher eukaryotes and illuminate the physiological and gene-selective roles of Mediator.

[Indexed for MEDLINE]

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