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Stroke. 2011 Sep;42(9):2611-4. doi: 10.1161/STROKEAHA.111.614313. Epub 2011 Aug 11.

Diabetes mellitus and risk of stroke and its subtypes among Japanese: the Japan public health center study.

Author information

1
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan, 2-2 Yamadaoka, Suita-shi, Osaka, 565-0871 Japan.

Abstract

BACKGROUND AND PURPOSE:

Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians.

METHODS:

A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions).

RESULTS:

The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex.

CONCLUSIONS:

Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese.

PMID:
21836098
DOI:
10.1161/STROKEAHA.111.614313
[Indexed for MEDLINE]
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