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Neuron. 2011 Aug 11;71(3):383-5. doi: 10.1016/j.neuron.2011.07.018.

Tracking down the molecular substrates of stress: new roles for p38α MAPK and kappa-opioid receptors.

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Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.


In this issue, Bruchas et al. (2011) uncover a novel stress-induced p38α MAPK signaling cascade within serotonergic neurons of the dorsal raphe nucleus that mediates depressive and drug-seeking behaviors. Their findings have potentially important implications for medication development.

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