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Cell Mol Life Sci. 2011 Oct;68(19):3201-7. doi: 10.1007/s00018-011-0784-5. Epub 2011 Aug 11.

Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell.

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1
Department of Biological Information, Tokyo Institute of Technology, Yokohama 226-8501, Japan. akudo@bio.titech.ac.jp

Abstract

More than 10 years have passed since the naming of periostin derived from its expression sites in the periosteum and periodontal ligament. Following this finding, we have accumulated more data on the expression patterns of periostin, and, finally, with the generation of periostin-deficient mice, have revealed functions of periostin in the regeneration of tissues in bone, tooth, heart, and skin, and its action in cancer invasion. Since periostin is a matricellular protein, the first investigation of periostin function showed its enhancement of cell migration by acting outside the cell. On the other hand, recent observations have demonstrated that periostin functions in fibrillogenesis in association with extracellular matrix molecules inside the cell.

PMID:
21833583
PMCID:
PMC3173633
DOI:
10.1007/s00018-011-0784-5
[Indexed for MEDLINE]
Free PMC Article
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