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Nature. 2011 Aug 10;476(7359):163-9. doi: 10.1038/nature10275.

A continuum model for tumour suppression.

Author information

1
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

This year, 2011, marks the forty-year anniversary of the statistical analysis of retinoblastoma that provided the first evidence that tumorigenesis can be initiated by as few as two mutations. This work provided the foundation for the two-hit hypothesis that explained the role of recessive tumour suppressor genes (TSGs) in dominantly inherited cancer susceptibility syndromes. However, four decades later, it is now known that even partial inactivation of tumour suppressors can critically contribute to tumorigenesis. Here we analyse this evidence and propose a continuum model of TSG function to explain the full range of TSG mutations found in cancer.

PMID:
21833082
PMCID:
PMC3206311
DOI:
10.1038/nature10275
[Indexed for MEDLINE]
Free PMC Article
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