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J Biol Chem. 2012 Feb 10;287(7):4434-40. doi: 10.1074/jbc.R111.271999. Epub 2011 Aug 10.

Signal transduction by mitochondrial oxidants.

Author information

1
Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. finkelt@nih.gov

Abstract

The production of mitochondrial reactive oxygen species occurs as a consequence of aerobic metabolism. Mitochondrial oxidants are increasingly viewed less as byproducts of metabolism and more as important signaling molecules. Here, I review several notable examples, including the cellular response to hypoxia, aspects of innate immunity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests an important regulatory role for mitochondrial oxidants.

PMID:
21832045
PMCID:
PMC3281633
DOI:
10.1074/jbc.R111.271999
[Indexed for MEDLINE]
Free PMC Article

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