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Microbiol Immunol. 2011 Nov;55(11):817-21. doi: 10.1111/j.1348-0421.2011.00378.x.

Activation of the alternative complement pathway by mannose-binding lectin via a C2-bypass pathway.

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1
Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan.

Abstract

MBL is a serum lectin that activates the lectin pathway of the complement system. MBL forms complexes with three types of MASPs. Upon binding to Salmonella serogroup C-specific oligosaccharide, MBL activates the alternative pathway via a C2-bypass pathway without involving MASP-2, C2 or C4. We demonstrate that mannan-bound MBL activates the alternative pathway via a C2-bypass pathway that requires MASP-2 and C4. Thus, depending on the ligands to which MBL binds, there may be two distinct MBL-mediated C2-bypass pathways.

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