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World J Biol Psychiatry. 2011 Oct;12(7):474-88. doi: 10.3109/15622975.2011.596220. Epub 2011 Aug 11.

The genetic blueprint of major depressive disorder: contributions of imaging genetics studies.

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1
Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Abstract

OBJECTIVES:

To review neuroimaging intermediate phenotypes of MDD and their relation to genetic risk variants.

METHODS:

A systematic literature search of peer-reviewed English language articels using PubMed ( www.pubmed.org ) was performed.

RESULTS:

Comprehensive evidence on the influence of serotonergic genes (SLC6A4, HTR1A, MAOA, TPH2) and BDNF on the following neural intermediate phenotypes is displayed: amygdala reactivity, coupling of amygdala-anterior cingulate cortex (ACC) activity, ACC volume, hippocampal volume and serotonin receptor 1A (5-HT1A) binding potential (BP).

CONCLUSIONS:

Intermediate phenotypes may bridge the gap between genotype and phenotype by reducing the impreciseness of psychiatric phenotypes and yield more insights into the underlying biology.

PMID:
21830992
DOI:
10.3109/15622975.2011.596220
[Indexed for MEDLINE]
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