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Ophthalmic Surg Lasers Imaging. 2011 Nov-Dec;42(6):460-7. doi: 10.3928/15428877-20110804-03. Epub 2011 Aug 11.

16-Gy low-voltage x-ray irradiation followed by as-needed ranibizumab therapy for AMD: 6-month outcomes of a "radiation-first" strategy.

Author information

1
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Department of Ophthalmology, Palm Beach Gardens, Florida, USA.

Abstract

BACKGROUND AND OBJECTIVE:

To describe the effect of a "radiation-first" combination treatment strategy for neovascular age-related macular degeneration (AMD) with ranibizumab rescue therapy.

PATIENTS AND METHODS:

Non-invasive, externally delivered low-voltage x-ray irradiation at a dose of 16 Gy was given in a single session through three locations in the inferior pars plana in a consecutive series of patients with neovascular AMD. Ranibizumab was administered according to prospectively determined criteria.

RESULTS:

Thirteen patients completed a 6-month follow-up. All patients lost 15 or fewer ETDRS letters, 7 gained 0 or more ETDRS letters, and 0 gained more than 15 ETDRS letters. Patients received a total of 15 ranibizumab injections following x-ray irradiation at baseline. Two patients received no ranibizumab injections, seven patients received 1 injection, and four patients received 2 injections.

CONCLUSION:

Low-voltage x-ray treatment followed by ranibizumab rescue demonstrates an independent visual acuity stabilizing effect for patients with wet AMD.

PMID:
21830745
DOI:
10.3928/15428877-20110804-03
[Indexed for MEDLINE]

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