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Chem Commun (Camb). 2011 Sep 28;47(36):10025-7. doi: 10.1039/c1cc13597j. Epub 2011 Aug 10.

Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.

Author information

1
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA.

Abstract

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

PMID:
21829824
PMCID:
PMC4091617
DOI:
10.1039/c1cc13597j
[Indexed for MEDLINE]
Free PMC Article

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