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Genes Dev. 2011 Aug 1;25(15):1557-62. doi: 10.1101/gad.17328611.

Return to youth with Sox17.

Author information

1
Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA.

Abstract

Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613-1627) show that overexpression of Sox17 can convert adult multipotential progenitors to self-renewing HSCs that possess fetal properties. These findings challenge the irreversibility of hematopoietic development, and open up new perspectives to understand the different forms of HSC self-renewal at distinct stages of ontogeny and during transformation.

PMID:
21828265
PMCID:
PMC3182022
DOI:
10.1101/gad.17328611
[Indexed for MEDLINE]
Free PMC Article

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