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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):e31-5. doi: 10.1016/j.tripleo.2011.04.007.

Antiviral effects of blackberry extract against herpes simplex virus type 1.

Author information

1
Department of Oral Health Practice, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA.

Abstract

OBJECTIVE:

The aim of this study was to evaluate antiviral properties of blackberry extract against herpes simplex virus type 1 (HSV-1) in vitro.

STUDY DESIGN:

HSV-infected oral epithelial (OKF6) cells and cell-free virus suspensions were treated with blackberry extract (2.24-1,400 μg/mL), and virus yield and infectivity were quantified by direct plaque assay.

RESULTS:

Blackberry extract ≥56 μg/mL inhibited HSV-1 replication in oral epithelial cells by >99% (P < .005). Concentrations ≥280 μg/mL were antiviral when the extract was added after virus adsorption and entry. Exposure of cell-free virus to ≥280 μg/mL blackberry extract for 15 minutes at room temperature was virucidal (P = .0002). The virucidal effects were not due to pH changes at concentrations up to 1,500 μg/mL.

CONCLUSIONS:

Blackberry extract inhibited the early stages of HSV-1 replication and had potent virucidal activity. These properties suggest that this natural fruit extract could provide advantage as a topical prophylactic/therapeutic agent for HSV infections.

PMID:
21827957
PMCID:
PMC3154751
DOI:
10.1016/j.tripleo.2011.04.007
[Indexed for MEDLINE]
Free PMC Article

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